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The organ transplantation is the ultimate treatment for many patients with end-stage organ failure. The number of transplanted and potential recipients remains limited due to many barriers which are not yet resolved. In the past, immunosuppressive drugs have been used to avoid graft rejection. However, the long-term use of these substances may lead to severe side effects. Hence, safer and more selective drugs are needed. Based on the knowledge about the molecular biology of the immune system, many new drugs are under development. Among these, the effector molecules for the immune response are also promising targets for development of drugs.AP-5 (Andrographolide) is a constituent of Andrographis paniculata Nees. This herb is also known as bai-xiang, and has been traditionally used to treat various ailments, including fever and infectious diseases. Andrographolide has the following structure.
It has been shown that AP-5 is the most potent cyclooxygenase inhibitor among the diterpene lactones present in the herb Andrographis. Interestingly, in rodents, AP-5 is metabolized to 18-O-β-D-glucopyranosyl-13β-hydroxyandrographolide (AP-3), which in turn
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